N-Glycans of Caenorhabditis elegans Are Specific to Developmental Stages
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چکیده
منابع مشابه
In Vivo Imaging of Caenorhabditis elegans Glycans
The nematode Caenorhabditis elegans is an excellent model organism for studies of glycan dynamics, a goal that requires tools for imaging glycans in vivo. Here we applied the bioorthogonal chemical reporter technique for the molecular imaging of mucin-type O-glycans in live C. elegans. We treated worms with azidosugar variants of N-acetylglucosamine (GlcNAc), N-acetylgalactosamine (GalNAc), and...
متن کاملCaenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation.
Mediator proteins are required for transcriptional regulation of most genes in yeast. Mammalian Mediator homologs also function as transcriptional coactivators in vitro; however, their physiological role in gene-specific transcription is not yet known. To determine the role of Mediator proteins in the development of complex organisms, we purified putative Mediator complexes from Caenorhabditis ...
متن کاملCore Richness of N-Glycans of Caenorhabditis elegans: A Case Study on Chemical and Enzymatic Release
Despite years of research, the glycome of the model nematode Caenorhabditis elegans is still not fully understood. Certainly, data over the years have indicated that this organism synthesizes unusual N-glycans with a range of galactose and fucose modifications on the Man2-3GlcNAc2 core region. Previously, up to four fucose residues were detected on its N-glycans, despite these lacking the fucos...
متن کاملControl of developmental timing in Caenorhabditis elegans.
Studies of the nematode Caenorhabditis elegans have identified genetic and molecular mechanisms controlling temporal patterns of developmental events. Mutations in genes of the C. elegans heterochronic pathway cause altered temporal patterns of larval development, in which cells at certain larval stages execute cell division patterns or differentiation programs normally specific for other stage...
متن کاملDevelopmental Biology of Caenorhabditis elegans: Symposium Introduction.
T h e comple te pos tembryon ic ceil l ineages of the free-l iving nenta todes Caenorhabditis elegans and Panagrellus redivivus are known. Pos tembryonic cell divisions lead to subs tan t ia l increases in the n u m b e r of cells and, in mos t cases, in the n u m b e r of types of cells in the neurona l , muscu la r , hypodermal , and digestive systems. T h e pa t te rns of pos tembyron ic cel...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m503828200